On Friday, 1st of November, Sebastian Hendrix defended his PhD thesis cum laude describing his work on the role of SPRING in regulating the SREBP pathway and lipid metabolism. The work included in the thesis describes how SREBP is required to promote the maturation of S1P, a protease that is required for the first cleavage-activation event of SREBPs. When SPRING is absent, SREBP cleavage cannot occur and as a consequence the SREBP pathway cannot be activated. The thesis positions SPRING as a core component of the SREBP activation machinery, the only new determinant added in the last 2 decades.