The Zelcer lab's study describing the structure of SPRING and S1P is out. This was a great collaboration with Daniel Kober (UTSW) who is a biochemsitry and CryoEM wizard. This study provides th structural basis for the role SPRING has in proteolytic maturation of the S1P zymogen, and why SPRING is required for S1P-mediated cleavage of the SREBP transcription factors. Enjoy the reading and let us know what you think of this:
https://www.nature.com/articles/s41467-024-50068-8
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Latest news Medical Biochemistry Amsterdam
At the annual Dutch Atherosclerosis Society (DAS) meeting, Lobke received the award for Best Flash Talk for her presentation on the role of LXR in macrophage immune activation, while Ricky was awarded Best Poster Presentation for his work on the role of IRF1 in macrophage function. Congratulations to both!
Ricky Siebeler won the best presentation award on the annual Amsterdam institute for Immunology and Infectious diseases (AII) symposium for his presentation on Endogenous Retroviral Elements as regulators of macrophage activation. Congratulations!!
