The Zelcer lab's study describing the structure of SPRING and S1P is out. This was a great collaboration with Daniel Kober (UTSW) who is a biochemsitry and CryoEM wizard. This study provides th structural basis for the role SPRING has in proteolytic maturation of the S1P zymogen, and why SPRING is required for S1P-mediated cleavage of the SREBP transcription factors. Enjoy the reading and let us know what you think of this:

https://www.nature.com/articles/s41467-024-50068-8